DEEP WORK

5. SIGNALING PATHWAYS IN THE DIFFERENTIATION OF CD4 AND CD8 T CELLSAs individual CD4 T cells commit to the Th1 or Th2 effector lineage to the exclusion of the other lineage, they have provided a well-utilized model in which to study cellular and molecular events involved in cell fate choices. Much less is known regarding the Th17 fate choice, although knowledge in this area is rapidly accruing. ..

1. INTRODUCTIONThe canonical Th1 cytokine, interferon-γ (IFN-γ), is critical for innate and adaptive immunity against viral and intracellular bacterial infections. In humans, genetic deficiencies in the interleukin (IL)-12/IL-23/IFN-γ pathways that result in decreased IFN-γ induction or signaling are associated with strikingly increased susceptibility to mycobacterial infections (Filipe-Santos e..