DEEP WORK

2.4.3 Antimicrobial peptidesAntimicrobial peptides (AMPs) are small peptides (less than 100 amino acids) with low molecular weight and direct microbicidal activities. They are mostly cationic and amphipathic, although some anionic peptides are included among them. AMPs are synthesized as pre-pro-peptides, and, once the active peptides are released by cleavage, they interact directly with pathoge..

Antimicrobial peptidesAntimicrobial peptides are increasingly recognized as a critical factor in host defence mechanism and found in organisms ranging from microbes, plants to animal species (Fernandes et al., 2004; Kennedy et al., 2009). It also plays an important role in fish when compared with mammals as fish rely more on their innate immune system (Hancock, 1997; Hancock and Scott, 2000). Fi..

Targeting microbial replicationDirect inhibition of microbial replication is executed by molecules that interfere with specific steps in the replication cycle of a given microorganism. There are at least six mechanisms of action in this category: restriction factors that directly block a specific replication step; restriction factors that deplete molecules essential for replication; RNA interfer..