DEEP WORK

NUCLEIC ACID–INDEPENDENT VIRAL RECOGNITIONRecognition of Viral Structural ProteinsIn addition to viral nucleic acids, other signatures of viruses or viral infection processes are detected by the host cells to trigger innate defenses. Of these defenses, stimulation of PRRs by viral structural proteins has been the target of intense research (29). Surface TLRs (Figure 1), including TLR2 and TLR4, ..

INTRODUCTIONViruses are the most abundant life form on earth, inhabiting nearly every ecosystem, including animals, plants, and bacteria. Research over the past decade has provided enormous insights into the mechanism by which viruses are detected by infected cells. It is clear that the innate immune system is equipped with multiple sensors that detect different molecular signatures of a viral i..