Fish immune system—an overview Like mammals, the fish immune system is built with two components, i.e., non-specifc, or innate immunity, and specifc or adaptive immunity. The nonspecifc immune system in fish is the second line of defence, which responds non-specifcally against pathogens before the specifc immune system takes command of the defence mechanism (Firdaus-Nawi and Zamri-Saad 2016). Bo..