DEEP WORK

The Mucosal Immune System of Teleost Fish

1. IntroductionFish are continuously exposed to a microbial-rich environment (freshwater or seawater) that circulates through and reaches every epithelial barrier of their body. Thus, compared to terrestrial animals, aquatic animals have a greater challenge coping with high microbial loads, which bombard their mucosal epithelial barriers. The main mucosa-associated lymphoid tissues (MALT) of tel..

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

INTRODUCTIONInterferons (IFNs) are pleiotropic cytokines with antiviral, antitumor and immunomodulatory properties, being central coordinators of the immune response (1). The term “interferons” comes from the description of molecules protecting cells by “interfering” with viral infection (2, 3). Three major types of IFNs are distinguished by their sequence identity, genetic loci, cell of origin,..