DEEP WORK

Induction of Regulatory Responses by the MicrobiotaMaintenance of tissue homeostasis is imperative for host survival. This fundamental process relies on a complex and coordinated set of innate and adaptive responses that selects and calibrates responses against self, food, commensals, and pathogens in the most appropriate manner. To this end, specialized populations of cells have to integrate lo..

IntroductionMulticellular organisms exist as meta-organisms comprised of both the macroscopic host and its symbiotic commensal microbiota. With an estimated composition of 100 trillion cells, human symbionts outnumber host cells by at least a factor of 10 and express at least 10-fold more unique genes than their host’s genome (Ley et al., 2006a). These complex communities of microbes that includ..