DEEP WORK

IntroductionInnate immunity is evolutionarily conserved and acts as the first line of host defence against pathogen infections. Detection of microbial pathogen is an essential step in the initiation of innate immune responses and is mediated by pattern recognition receptors (PRRs; Janeway & Medzhitov 2002; Takeuchi & Akira 2010). PRRs are microbial sensors of the innate immune system that can re..

I. INTRODUCTION Our understanding of physiology has benefited greatly from the advances in molecular biology that have been at the origin of the explosive development of genetics and -omic techniques. What used to be a rarity a few decades ago, studying the expression and function of a given molecule within a different physiological system from the one in which it was first identified, has now b..

1. IntroductionFollowing virus challenge, fish mount an early antiviral response by activating the innate immune system [1–3] and later on another response takes place in the way of antibody production [4,5] and cytotoxic T-cell immunity [6]. Here, the focus will be set on the activation of five genes in the interferon pathway that could be regarded as the most relevant in the response to viral ..