DEEP WORK

Regulation of Interferon-γ During Innate and Adaptive Immune Responses- 1. INTRODUCTION

1. INTRODUCTIONThe canonical Th1 cytokine, interferon-γ (IFN-γ), is critical for innate and adaptive immunity against viral and intracellular bacterial infections. In humans, genetic deficiencies in the interleukin (IL)-12/IL-23/IFN-γ pathways that result in decreased IFN-γ induction or signaling are associated with strikingly increased susceptibility to mycobacterial infections (Filipe-Santos e..

Interferon-Stimulated Genes : A Complex Web of Host Defenses(진행중)

INTRODUCTIONThe interferon (IFN)-mediated innate immune response, selected by evolution, is hardwired within genomes and provides a robust first line of defense against invading pathogens. Following pathogen detection and subsequent IFN production, IFN molecules bind to cell surface receptors and initiate a signaling cascade through the Janus kinase signal transducer and activator of transcripti..